BIOCOMPATIBILITY OF LEUKOCYTE REMOVAL FILTERS DURING BEDSIDE LEUKOCYTE FILTRATION OF RED-CELL CONCENTRATES

被引：9

作者：

GU, YJ ^{[1
]}

OBSTER, R ^{[1
]}

DEHAAN, J ^{[1
]}

HUET, RCGG ^{[1
]}

VANOEVEREN, W ^{[1
]}

机构：

[1] UNIV GRONINGEN HOSP,THORAX CTR,DIV CARDIOPULM SURG RES,59 OOSTERSINGEL,9713 EZ GRONINGEN,NETHERLANDS

来源：

TRANSFUSION SCIENCE | 1992年 / 13卷 / 04期

关键词：

D O I：

10.1016/0955-3886(92)90035-F

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The biocompatibility of leukocyte removal filters was evaluated in four different types of leukocyte filters made from different materials during bedside leukocyte filtration of red cell concentrates (RCC). Two units of banked RCC were filtrated through each leukocyte filter inserted into the transfusion line (n=20). The results indicate that there was no significant increase of granulocyte elastase nor the generation of the complement split product C3a during filtration of the first unit of RCC. However, activation of the complement system occurred during filtration of the second unit of RCC in particular by the filters made from cellulose acetate. There was no increase of either clotting or fibrinolytic activity during leukocyte filtration by all these leukocyte removal filters. Samples taken from patients revealed that no increase of these bioactive substances was found in patients who received the transfusion through leukocyte filters. Thus, the evaluated leukocyte removal filters do not compromise patients in terms of biocompatibility and are safe to be used during bedside filtration.

引用

页码：467 / 472

页数：6

共 12 条

[1]

Gilbert, Hayes, Hudson, James, Prevention of transfusion-acquired cytomegalovirus infection in infants by blood transfusion to remove leukocytes, Lancet, 1, pp. 1228-1231, (1989)

[2]

Rawal, Busch, Endow, Et al., Reduction of human immunodeficiency virus-infected cells from donor blood by leukocyte filtration, Transfusion, 29, pp. 460-462, (1989)

[3]

Sirchia, Rebulla, Parravicini, Carnelli, Gianotti, Bertolini, Leukocyte depletion of red cell units at the bedside by transfusion through a new filter, Transfusion, 27, pp. 402-405, (1987)

[4]

Pietersz, Dekker, Reesink, A new cellulose acetate filter to remove leukocytes from buffy-coat-poor red cell concentrates, Vox Sang, 56, pp. 37-39, (1989)

[5]

Craddock, Fehr, Brigham, Kronenberg, Jacob, Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis, N Engl J Med, 296, pp. 769-774, (1977)

[6]

Chenoweth, Biocompatibility of hemodialysis membranes. Evaluation with C3a anaphylatoxin radioimmunoassays, ASAIO J, 7, pp. 44-49, (1984)

[7]

Kirklin, Westaby, Blackstone, Kirklin, Chenoweth, Pacifico, Complement and the damaging effects of cardiopulmonary bypass, J Thorac Cardiovasc Surg, 86, pp. 845-857, (1983)

[8]

van Oeveren, Wildevuur, Review article : Blood compatibility of cardiopulmonary bypass circuits, Perfusion, 2, pp. 237-244, (1987)

[9]

Gu, van Oeveren, Boonstra, de Haan, Wildevuur, Leukocyte activation with increased membrane expression of CR3 receptors induced by cardiopulmonary bypass, Ann Thorac Surg, 53, pp. 839-843, (1992)

[10]

Pangburn, Schreiber, Muller-Eberhard, C3b deposition during activation of the alternative complement pathway and the effect of deposition on the activating surface, J Immunol, 131, pp. 1930-1935, (1983)

← 1 2 →