WRIGHTIADIONE FROM WRIGHTIA-TOMENTOSA

被引：40

作者：

LIN, LJ

TOPCU, G

LOTTER, H

RUANGRUNGSI, N

WAGNER, H

PEZZUTO, JM

CORDELL, GA

机构：

[1] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612

[2] UNIV MUNICH,INST PHARMAZEUT BIOL,W-8000 MUNICH 2,GERMANY

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 12期

关键词：

WRIGHTIA-TOMENTOSA; APOCYNACEAE; ISOFLAVONE; WRIGHTIADIONE; SELECTIVE INEPT NMR SPECTROSCOPY; X-RAY CRYSTALLOGRAPHY;

D O I：

10.1016/0031-9422(92)80469-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel isoflavone wrightiadione, was isolated from Wrightia tomentosa. Determination of the carbon framework was based on the interpretation of NMR and mass spectral data, and the structure was confirmed by X-ray analysis. This compound displays cytotoxic activity against the murine P388 lymphocytic leukemia cell line (ED50, 1.1 mug ml-1).

引用

页码：4333 / 4335

页数：3

共 13 条

[1] POTENTIAL ANTICANCER AGENTS .31. N-DEMETHYLATION OF FAGARONINE [J].

ARISAWA, M ;

PEZZUTO, JM ;

BEVELLE, C ;

CORDELL, GA .

JOURNAL OF NATURAL PRODUCTS, 1984, 47 (03) :453-458

[2] STRUCTURE DETERMINATION AND SPECTRAL ASSIGNMENT BY PULSED POLARIZATION TRANSFER VIA LONG-RANGE H-1-C-13 COUPLINGS [J].

BAX, A .

JOURNAL OF MAGNETIC RESONANCE, 1984, 57 (02) :314-318

[3]

CORDELL GA, 1991, TETRAHEDRON, V47, P3251

[4]

DANIEL M, 1978, INDIAN J EXP BIOL, V16, P512

[5]

HARBORNE JB, 1982, FLAVONOIDS ADV RES, P535

[6]

JAYASWAL S B, 1977, Indian Journal of Pharmacy, V39, P37

[7] SEPARATION OF ALKALOIDAL CONSTITUENTS OF WRIGHTIA TOMENTOSA BY PAPER PARTITION CHROMATOGRAPHY [J].

JAYASWAL, SB ;

BASU, NK .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (02) :315-&

[8]

KALINOWSKI H, 1988, CARBON 13 NMR SPECTR, P310

[9]

LIKHITWITAYAWUID K, 1992, IN PRESS J NAT PROD

[10]

MOKKHASMIT M, 1971, Journal of the Medical Association of Thailand, V54, P490

← 1 2 →