POTENT ANTI-HIV AND ANTI-HBV ACTIVITIES OF (-)-L-BETA-DIOXOLANE-C AND (+)-L-BETA-DIOXOLANE-T AND THEIR ASYMMETRIC SYNTHESES

被引：81

作者：

KIM, HO

SHANMUGANATHAN, K

ALVES, AJ

JEONG, LS

BEACH, JW

SCHINAZI, RF

CHANG, CN

CHENG, YC

CHU, CK

机构：

[1] UNIV GEORGIA,COLL PHARM,DEPT MED CHEM,ATHENS,GA 30602

[2] EMORY UNIV,SCH MED,VET ADM MED CTR,DEPT PEDIAT,DECATUR,GA 30033

[3] YALE UNIV,SCH MED,DEPT PHARMACOL,NEW HAVEN,CT 06510

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 46期

关键词：

ANTI-HIV; ANTI-HBV; (+)-L-BETA-DIOXOLANE-T; (-)-L-BETA-DIOXOLANE-C; ASYMMETRIC SYNTHESIS;

D O I：

10.1016/S0040-4039(00)60890-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric syntheses of (+)-L-beta-dioxolane-T and (-)-L-beta-dioxolane-C were accomplished starting from 1,6-anhydro-L-beta-gulopyranose, and their anti-HIV and anti-HBV activities were evaluated in human PBM cells, CEM cells and 2.2.15 cells, respectively.

引用

收藏

页码：6899 / 6902

页数：4

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