GTP-GAMMA-S-INDUCED PHOSPHORYLATION OF MYOSIN LIGHT-CHAIN KINASE IN SMOOTH-MUSCLE

被引：13

作者：

TANG, DC

KUBOTA, Y

KAMM, KE

STULL, JT

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT PHYSIOL,5323 HARRY HINES BLVD,DALLAS,TX 75235

[2] KYUSHU UNIV,FAC DENT,DEPT ORAL SURG 2,FUKUOKA 812,JAPAN

来源：

FEBS LETTERS | 1993年 / 331卷 / 03期

关键词：

SMOOTH MUSCLE CONTRACTION; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN KINASE; GTP-GAMMA-S; PROTEIN PHOSPHATASE;

D O I：

10.1016/0014-5793(93)80351-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorylation of myosin light chain kinase by a Ca2+-dependent protein kinase increases the concentration of Ca2+/calmodulin required for half-maximal activation. The Ca2+ concentrations required for myosin light chain kinase phosphorylation in permeable smooth muscle are similar to those required for myosin light chain phosphorylation. Both GTPgammaS and carbachol increase the Ca2+ sensitivity of myosin light chain kinase phosphorylation as well as light chain phosphorylation. It is proposed that a similar G-protein mediated mechanism regulates the Ca2+-dependent phosphorylation of these two contractile proteins in smooth muscle.

引用

页码：272 / 275

页数：4

共 19 条

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