TRANSCRIPTIONAL ACTIVATION BY THE ADENOVIRUS E1A PROTEINS

被引：19

作者：

NEVINS, JR

机构：

[1] Howard Hughes Medical Institute, Section of Genetics, Duke University Medical Center, Durham

来源：

SEMINARS IN VIROLOGY | 1993年 / 4卷 / 01期

关键词：

ADENOVIRUS; E1A; TRANSACTIVATION; E2F; RB;

D O I：

10.1016/1044-5773(93)80005-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The viruses that infect animal cells, particularly those viruses that replicate in the nucleus of cells, have provided important models for the study of transcriptional regulation. The adenovirus E1A gene encodes proteins that regulate both viral and cellular transcription. Recent studies have provided insights into the molecular mechanisms for transcriptional control by the E1A proteins that include interactions with various cellular transcription factors. Moreover, these studies have also helped to illuminate at least a part of the process by which the E1A12S product functions as an oncogene. © 1993 Academic Press Ltd.

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页码：25 / 31

页数：7

相关论文

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