RANTES AUGMENTS RADICAL OXYGEN PRODUCTS FROM EOSINOPHILS

被引：28

作者：

CHIHARA, J

HAYASHI, N

KAKAZU, T

YAMAMOTO, T

KURACHI, D

NAKAJIMA, S

机构：

[1] KANSAI MED UNIV, DEPT PEDIAT, OSAKA, JAPAN

[2] UNIV RYUKYUS, SCH MED, OKINAWA, JAPAN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 104卷

关键词：

RANTES; EOSINOPHILS; CHEMOKINES; RADICAL OXYGEN PRODUCTS; CHEMILUMINESCENCE; PLATELET FACTOR 4; PLATELETS;

D O I：

10.1159/000236752

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

RANTES, which is released from thrombin-stimulated platelets, is a member of the 8-kD cytokine family that has been shown to possess chemotactic activity for eosinophils. Thus, in this study, we examined the effect of RANTES on radical oxygen products from eosinophils. RANTES treatment resulted in the enhancement of peak value and intergrated value of productivity of eosinophil-mediated radical oxygen products determined by luminol-dependent chemiluminescence of EoL-3 cells stimulated with A23187. In addition, the radical oxygen products of EoL-1 or eosinophils showed similar results. Thus, we could conclude that platelets might play an important role in the pathogenesis of allergic inflammation through the involvement in the selective eosinophil infiltration and eosinophil activation by releasing RANTES.

引用

页码：52 / 53

页数：2

共 15 条

[1]

ALAM R, 1993, J IMMUNOL, V150, P3442

[2] EOSINOPHILIC INFLAMMATION IN ASTHMA [J].

BOUSQUET, J ;

CHANEZ, P ;

LACOSTE, JY ;

BARNEON, G ;

GHAVANIAN, N ;

ENANDER, I ;

VENGE, P ;

AHLSTEDT, S ;

SIMONYLAFONTAINE, J ;

GODARD, P ;

MICHEL, FB .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (15) :1033-1039

[3] NEW FUNCTIONS FOR PLATELETS AND THEIR PATHOLOGICAL IMPLICATIONS [J].

CAPRON, A ;

AMEISEN, JC ;

JOSEPH, M ;

AURIAULT, C ;

TONNEL, AB ;

CAEN, J .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1985, 77 (1-2) :107-114

[4] INDUCTION OF HYPODENSE EOSINOPHILS AND NUCLEAR HYPERSEGMENTATION OF EOSINOPHILS BY VARIOUS CHEMOTACTIC FACTORS AND LYMPHOKINES INVITRO [J].

CHIHARA, J ;

NAKAJIMA, S .

ALLERGY PROCEEDINGS, 1989, 10 (01) :27-32

[5]

Chihara J, 1992, Eur Cytokine Netw, V3, P53

[6]

CHIHARA J, 1991, ALLERGY CLIN IMMUN S, V1, P144

[7]

CHIHARA J, 1989, EOSINOPHILS ASTHMA, P151

[8]

CHIHARA J, 1990, CELLS ASTHMA, P123

[9]

Chihara Junichi, 1993, Biotechnology Therapeutics, V4, P271

[10]

GLEICH GJ, 1986, ADV IMMUNOL, V39, P77

← 1 2 →