RE-ENTRANT ROTATING WAVES IN A BEELER-REUTER BASED MODEL OF TWO-DIMENSIONAL CARDIAC ELECTRICAL ACTIVITY

被引:141
作者
Courtemanche, Marc [1 ]
Winfree, Arthur T. [2 ]
机构
[1] Univ Arizona, Dept Appl Math, Tucson, AZ 85721 USA
[2] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA
来源
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS | 1991年 / 1卷 / 02期
关键词
D O I
10.1142/S0218127491000336
中图分类号
O1 [数学];
学科分类号
0701 ; 070101 ;
摘要
Propagation of cardiac electrical activity is simulated in a two-dimensional sheet of cells using the cable equation and the Beeler-Reuter membrane model for ventricular muscle cells. Re-entrant patterns are produced using the original Beeler-Reuter equations and two modified versions involving changes in the calcium and sodium channel dynamics. Both stable rotating waves and irregular activity are observed. The model is shown to exhibit conduction block due to stationary repolarization fronts. The origin and properties of these fronts are described.
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页码:431 / 444
页数:14
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