A COLLAGEN-POLYPYRROLE HYBRID - INFLUENCE OF 3-BUTANESULFONATE SUBSTITUTION

被引：20

作者：

LI, HC

KHOR, E

机构：

[1] Department of Chemistry, National University of Singapore, Kent Ridge

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 1995年 / 196卷 / 06期

关键词：

D O I：

10.1002/macp.1995.021960601

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Hybrid biomaterials derived from a water-soluble derivative of polypyrrole, poly[sodium 4-(3-pyrrolyl)butanesulfonate], and soluble collagen have been synthesized by chemical polymerization of the 4-(3-pyrrolyl)butanesulfonate monomer in a collagen solution. Interaction between the two polymers was evident in the formation of a precipitated black polymer-collagen gel obtained for a monomer concentration of 0,01 mol/L. The collagen content in the gel was determined to be around 38 wt-%. When the monomer concentration was increased five-fold, the product was a dispersed precipitate that was polymer rich with a corresponding decrease in collagen (11 wt-%) content. Fourier transform infrared spectroscopy and thermal analysis of the hybrids provide signs of interaction between the sulfonic acid group on the substituted pyrrole and side groups of amino acids in collagen. The electrical conductivities of these hybrid biomaterials were found to be in the 10(-2) S cm(-1) range.

引用

页码：1801 / 1812

页数：12

共 14 条

[1]

BLYTHE AR, 1979, ELECTRICAL PROPERTIE, P132

[2]

Chvapil M, 1973, Int Rev Connect Tissue Res, V6, P1

[3]

GIUSTI P, 1993, TRENDS POLYM SCI, V1, P261

[4]

GOTT VL, 1961, SURGERY, V50, P382

[5] Water-Soluble Self-Doped 3-Substituted Polypyrroles [J].

Havinga, E. E. ;

ten Hoeve, W. ;

Meijer, E. W. ;

Wynberg, H. .

CHEMISTRY OF MATERIALS, 1989, 1 (06) :650-659

[6]

HEPEL M, 1992, POLYM PREP AM CHEM S, V33, P106

[7] REGIOSELECTIVE SYNTHESIS OF ACYLPYRROLES [J].

KAKUSHIMA, M ;

HAMEL, P ;

FRENETTE, R ;

ROKACH, J .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (19) :3214-3219

[8] INTERACTION OF COLLAGEN WITH POLYPYRROLE IN THE PRODUCTION OF HYBRID MATERIALS [J].

LI, HC ;

KHOR, E .

POLYMER INTERNATIONAL, 1994, 35 (01) :53-59

[9] CHEMICAL SYNTHESIS OF HIGHLY ELECTRICALLY CONDUCTIVE POLYPYRROLE [J].

MACHIDA, S ;

MIYATA, S ;

TECHAGUMPUCH, A .

SYNTHETIC METALS, 1989, 31 (03) :311-318

[10]

MILLER EJ, 1982, METHOD ENZYMOL, V82, P33

← 1 2 →