INFLAMMATORY CELLS IN NORMAL HUMAN FRACTURE-HEALING

被引:98
作者
ANDREW, JG [1 ]
ANDREW, SM [1 ]
FREEMONT, AJ [1 ]
MARSH, DR [1 ]
机构
[1] UNIV MANCHESTER, DEPT PATHOL SCI, MANCHESTER M13 9PT, LANCS, ENGLAND
来源
ACTA ORTHOPAEDICA SCANDINAVICA | 1994年 / 65卷 / 04期
关键词
D O I
10.3109/17453679408995493
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
We studied inflammatory cells in specimens of callus taken from normally healing human fractures. Using immunohistochemistry, T-cells, B-cells, macrophages, HLA-DR expression and endothelial proliferation were assessed. Macrophages were present from an early stage but became less numerous later. T-cells were initially specifically recruited into the fracture site at the stage of granulation tissue, but subsequently excluded from areas of bone and cartilage formation. Inflammatory cells may control and coordinate fracture healing as has been proposed for soft tissue wound healing. The most likely mechanism for this is by the cytokines and growth factors which they are known to release.
引用
收藏
页码:462 / 466
页数:5
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