THERAPY OF MULTIDRUG-RESISTANT TYPHOID-FEVER WITH ORAL CEFIXIME VS INTRAVENOUS CEFTRIAXONE

被引:34
作者
BHUTTA, ZA
KHAN, IA
MOLLA, AM
机构
[1] Division of pediatrics, Aga Khan university hospital, Karachi, 74800, P.O. Box 3500, Stadium Road
关键词
MULTIDRUG-RESISTANT TYPHOID; CEFIXIME; CEFTRIAXONE;
D O I
10.1097/00006454-199411000-00010
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We randomly allocated 80 children with suspected multidrug-resistant tyhpoid fever to therapy with either cefixime or ceftriaxone. Of these, an alternative diagnosis was subsequently made in 10 children and another 10 were excluded because cultures were negative. In 9 cases the typhoidal organisms isolated were susceptible to first-line drugs. In all, 50 children were randomly allocated to receive therapy with either intravenous ceftriaxone (65 mg/kg/day once daily, Group A, n = 25) or oral cefixime (10 mg/kg/day divided every 12 hours, Group B, n = 25) for 14 days. The two groups were comparable in their clinical characteristics, duration and severity of illness at the time of admission. The time to defervescence was comparable in both groups (8.3 +/- 3.7 vs. 8.0 +/- 4.1 days, P = not significant). An equal number (3 in each group) failed to respond and underwent a change in therapy. Three children in Group A and one in Group B relapsed. No adverse effects were seen in either group during the course of therapy. Our data suggest that oral cefixime can be used as effectively as parenterally administered ceftriaxone for management of typhoid fever in children.
引用
收藏
页码:990 / 994
页数:5
相关论文
共 35 条
  • [1] CEFIXIME - SPECTRUM OF ANTIBACTERIAL ACTIVITY AGAINST 16016 CLINICAL ISOLATES
    BARRY, AL
    JONES, RN
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1987, 6 (10) : 954 - 957
  • [2] BAUER AW, 1966, AM J CLIN PATHOL, V45, P493
  • [3] BAVDEKAR A, 1991, Indian Journal of Pediatrics, V58, P335, DOI 10.1007/BF02754962
  • [4] BHUTTA ZA, 1991, REV INFECT DIS, V13, P832
  • [5] REVIEW OF CEFIXIME IN THE TREATMENT OF OTITIS-MEDIA IN INFANTS AND CHILDREN
    BLUESTONE, CD
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1993, 12 (01) : 75 - 82
  • [6] THE PHARMACOKINETIC AND BACTERICIDAL CHARACTERISTICS OF ORAL CEFIXIME
    BRITTAIN, DC
    SCULLY, BE
    HIROSE, T
    NEU, HC
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1985, 38 (05) : 590 - 594
  • [7] BRYAN JP, 1986, REV INFECT DIS, V8, P189
  • [8] INTERLEUKIN-6, GAMMA-INTERFERON, AND TUMOR-NECROSIS-FACTOR RECEPTORS IN TYPHOID-FEVER RELATED TO OUTCOME OF ANTIMICROBIAL THERAPY
    BUTLER, T
    HO, M
    ACHARYA, G
    TIWARI, M
    GALLATI, H
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (11) : 2418 - 2421
  • [9] ONCE DAILY CEFIXIME COMPARED WITH TWICE DAILY TRIMETHOPRIM SULFAMETHOXAZOLE FOR TREATMENT OF URINARY-TRACT INFECTION IN INFANTS AND CHILDREN
    DAGAN, R
    EINHORN, M
    LANG, R
    POMERANZ, A
    WOLACH, B
    MIRON, D
    RAZ, R
    WEINTRAUB, A
    STEINBERGER, J
    ISAACHSON, M
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1992, 11 (03) : 198 - 203
  • [10] DAR L, 1992, Indian Journal of Pediatrics, V59, P221, DOI 10.1007/BF02759988