METHAQUALONE METABOLITES AND THEIR SIGNIFICANCE IN ACUTE INTOXICATION

Blood and urine samples from an acutely Intoxicated patient who ingested methaqualone were studied. Four major monohydroxylated metabolltes were found, conjugated, in the urine. Another, 2-methyl-3[2-(hydroxymothyl)phonyl]-4 (3H) quinazolinone appears unconJugated In both blood and urine and should be considered in assessing toxic effects following methaqualono Ingestion. The concentration of metabolite II may indicate the time elapsed between ingestion and the time of collection of the specimen, while the amount of metabolite IV may indicate drug tolerance. © 1979 Oxford University Press.