EFFECT OF THE 8-AMINOQUINOLINE PRIMAQUINE ON CULTURE-DERIVED GAMETOCYTES OF THE MALARIA PARASITE PLASMODIUM-FALCIPARUM

被引：35

作者：

LANNERS, HN ^{[1
]}

机构：

[1] TULANE UNIV, MED CTR, SCH PUBL HLTH & TROP MED, DEPT TROP MED, NEW ORLEANS, LA 70112 USA

来源：

PARASITOLOGY RESEARCH | 1991年 / 77卷 / 06期

关键词：

D O I：

10.1007/BF00928413

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Gametocytes from the Honduras I/CDC clone HB-3 of Plasmodium falciparum were exposed to different concentrations of primaquine diphosphate. It could be shown that the drug acts specifically on the mitochondria of the cells by destroying their internal structure and causing these organelles to swell.

引用

页码：478 / 481

页数：4

共 22 条

[1]

AIKAWA M, 1969, MIL MED, V134, P986

[2] COMPARATIVE FINE STRUCTURE STUDY OF GAMETOCYTES OF AVIAN REPTILIAN AND MAMMALIAN MALARIAL PARASITES [J].

AIKAWA, M ;

HUFF, CG ;

SPRINZ, H .

JOURNAL OF ULTRASTRUCTURE RESEARCH, 1969, 26 (3-4) :316-+

[3] PLASMODIUM-FALLAX - HIGH-RESOLUTION AUTORADIOGRAPHY OF EXOERYTHROCYTIC STAGES TREATED WITH PRIMAQUINE IN-VITRO [J].

AIKAWA, M ;

BEAUDOIN, RL .

EXPERIMENTAL PARASITOLOGY, 1970, 27 (03) :454-&

[4]

BEAUDOIN RL, 1968, SCIENCE, V160, P1233, DOI 10.1126/science.160.3833.1233

[5] GAMETOCYTE-FORMING AND NON-GAMETOCYTE-FORMING CLONES OF PLASMODIUM-FALCIPARUM [J].

BHASIN, VK ;

TRAGER, W .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1984, 33 (04) :534-537

[6] THE CHEMOTHERAPY OF RODENT MALARIA .34. CAUSAL PROPHYLAXIS .3. ULTRASTRUCTURAL-CHANGES INDUCED IN EXO-ERYTHROCYTIC SCHIZONTS OF PLASMODIUM-YOELII-YOELII BY PRIMAQUINE [J].

BOULARD, Y ;

LANDAU, I ;

MILTGEN, F ;

ELLIS, DS ;

PETERS, W .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1983, 77 (06) :555-568

[7]

CARSON PE, 1984, HDB EXPT PHARM, V68, P83

[8]

Carter R, 1979, Bull World Health Organ, V57 Suppl 1, P37

[9] CHEMOTHERAPY OF RODENT MALARIA .13. FINE STRUCTURAL CHANGES OBSERVED IN ERYTHROCYTIC STAGES OF PLASMODIUM-BERGHEI-BERGHEI FOLLOWING EXPOSURE TO PRIMAQUINE AND MENOCTONE [J].

HOWELLS, RE ;

PETERS, W ;

FULLARD, J .

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1970, 64 (02) :203-&

[10] Complete in vitro maturation of Plasmodium falciparum gametocytes [J].

Ifediba, T. ;

Vanderberg, J. P. .

NATURE, 1981, 294 (5839) :364-366

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