INVIVO SPECTROPHOTOMETRIC EVALUATION OF NEOPLASTIC AND NONNEOPLASTIC SKIN PIGMENTED LESIONS .1. REFLECTANCE MEASUREMENTS

被引:62
作者
MARCHESINI, R
BRAMBILLA, M
CLEMENTE, C
MANIEZZO, M
SICHIROLLO, AE
TESTORI, A
VENTUROLI, DR
CASCINELLI, N
机构
[1] IST NAZL STUDIO & CURA TUMORI,DEPT PATHOL & CYTOPATHOL,I-20133 MILAN,ITALY
[2] IST NAZL STUDIO & CURA TUMORI,DEPT CLIN ONCOL B,I-20133 MILAN,ITALY
关键词
D O I
10.1111/j.1751-1097.1991.tb08470.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Reflectance spectrophotometry from 400 to 800 nm on different cutaneous pigmented lesions, including primary and metastatic malignant melanoma, pigmented nevi, lentigo and seborrhoeic keratosis, has been performed by using an external integrating sphere coupled to a spectrophotometer. Measurements show that reflectance spectra of the different lesions manifest dissimilar patterns, particularly in the near IR region. Comparison of reflectance of nevi with that of malignant melanomas results in a highly significant difference (P < 10-6) between the two samples. Though interpretation of the spectra remains difficult as a result of the complexity of the optical processes of scattering and absorption, our results suggest that a detailed analysis of the reflectance spectrum may give clinically useful information, and could be utilized as an aid in clinical diagnosis of cutaneous pigmented lesions, especially where malignant melanoma is concerned.
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页码:77 / 84
页数:8
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