MOTOR-NEURON DISEASES AND AMYOTROPHIC-LATERAL-SCLEROSIS - GM1 ANTIBODIES AND PARAPROTEINEMIA

被引：40

作者：

SANDERS, KA ^{[1
]}

ROWLAND, LP ^{[1
]}

MURPHY, PL ^{[1
]}

YOUNGER, DS ^{[1
]}

LATOV, N ^{[1
]}

SHERMAN, WH ^{[1
]}

PESCE, M ^{[1
]}

LANGE, DJ ^{[1
]}

机构：

[1] COLUMBIA PRESBYTERIAN MED CTR,NEW YORK NEUROL INST,ELEANOR & LOU GEHRIG MDA ALS CTR,NEW YORK,NY 10032

来源：

NEUROLOGY | 1993年 / 43卷 / 02期

关键词：

D O I：

10.1212/WNL.43.2.418

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Six of 110 patients (5.5%) with forms of motor neuron disease had abnormal titers of GM1 antibodies of 1:1,600 or higher. Four others came with previously known high titers. Three patients with upper motor neuron (UMN) signs had titers of 1,600; those with probable or no UMN signs had higher titers. Nine patients had conduction block; six of them had abnormal antibody titers, four with 6,400 or higher. Therefore, patients with motor neuron disease and abnormal anti-GM1 titers may have UMN signs or conduction block.

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页码：418 / 420

页数：3

相关论文

共 10 条

[1] EVALUATION OF MONOCLONAL GAMMOPATHIES IN THE WELL ELDERLY [J].

CRAWFORD, J ;

EYE, MK ;

COHEN, HJ .

AMERICAN JOURNAL OF MEDICINE, 1987, 82 (01) :39-45

[2] MULTIFOCAL MOTOR NEUROPATHY WITH CONDUCTION BLOCK - IS IT A DISTINCT CLINICAL ENTITY [J].

LANGE, DJ ;

TROJABORG, W ;

LATOV, N ;

HAYS, AP ;

YOUNGER, DS ;

UNCINI, A ;

BLAKE, DM ;

HIRANO, M ;

BURNS, SM ;

LOVELACE, RE ;

ROWLAND, LP .

NEUROLOGY, 1992, 42 (03) :497-505

[3] PATTERNS OF SERUM IGM ANTIBODIES TO GM1 AND GD1A GANGLIOSIDES IN AMYOTROPHIC LATERAL SCLEROSIS [J].

PESTRONK, A ;

ADAMS, RN ;

CORNBLATH, D ;

KUNCL, RW ;

DRACHMAN, DB ;

CLAWSON, L .

ANNALS OF NEUROLOGY, 1989, 25 (01) :98-102

[4] LOWER MOTOR-NEURON SYNDROMES DEFINED BY PATTERNS OF WEAKNESS, NERVE-CONDUCTION ABNORMALITIES, AND HIGH TITERS OF ANTIGLYCOLIPID ANTIBODIES [J].

PESTRONK, A ;

CHAUDHRY, V ;

FELDMAN, EL ;

GRIFFIN, JW ;

CORNBLATH, DR ;

DENYS, EH ;

GLASBERG, M ;

KUNCL, RW ;

OLNEY, RK ;

YEE, WC .

ANNALS OF NEUROLOGY, 1990, 27 (03) :316-326

[5] A TREATABLE MULTIFOCAL MOTOR NEUROPATHY WITH ANTIBODIES TO GM1 GANGLIOSIDE [J].

PESTRONK, A ;

CORNBLATH, DR ;

ILYAS, AA ;

BABA, H ;

QUARLES, RH ;

GRIFFIN, JW ;

ALDERSON, K ;

ADAMS, RN .

ANNALS OF NEUROLOGY, 1988, 24 (01) :73-78

[6] SERUM ANTIBODIES TO GM1 GANGLIOSIDE IN AMYOTROPHIC LATERAL SCLEROSIS [J].

PESTRONK, A ;

ADAMS, RN ;

CLAWSON, L ;

CORNBLATH, D ;

KUNCL, RW ;

GRIFFIN, D ;

DRACHMAN, DB .

NEUROLOGY, 1988, 38 (09) :1457-1461

[7] THE SPECTRUM OF NEUROLOGIC DISEASE ASSOCIATED WITH ANTI-GM1 ANTIBODIES [J].

SADIQ, SA ;

THOMAS, FP ;

KILIDIREAS, K ;

PROTOPSALTIS, S ;

HAYS, AP ;

LEE, KW ;

ROMAS, SN ;

KUMAR, N ;

VANDENBERG, L ;

SANTORO, M ;

LANGE, DJ ;

YOUNGER, DS ;

LOVELACE, RE ;

TROJABORG, W ;

SHERMAN, WH ;

MILLER, JR ;

MINUK, J ;

FEHR, MA ;

ROELOFS, RI ;

HOLLANDER, D ;

NICHOLS, FT ;

MITSUMOTO, H ;

KELLEY, JJ ;

SWIFT, TR ;

MUNSAT, TL ;

LATOV, N .

NEUROLOGY, 1990, 40 (07) :1067-1072

[8] IGM DEPOSITS AT NODES OF RANVIER IN A PATIENT WITH AMYOTROPHIC-LATERAL-SCLEROSIS, ANTI-GM1 ANTIBODIES, AND MULTIFOCAL MOTOR CONDUCTION BLOCK [J].

SANTORO, M ;

THOMAS, FP ;

FINK, ME ;

LANGE, DJ ;

UNCINI, A ;

WADIA, NH ;

LATOV, N ;

HAYS, AP .

ANNALS OF NEUROLOGY, 1990, 28 (03) :373-377

[9] MOTOR-NEURON DISEASE AND AMYOTROPHIC LATERAL SCLEROSIS - RELATION OF HIGH CSF PROTEIN-CONTENT TO PARAPROTEINEMIA AND CLINICAL SYNDROMES [J].

YOUNGER, DS ;

ROWLAND, LP ;

LATOV, N ;

SHERMAN, W ;

PESCE, M ;

LANGE, DJ ;

TROJABORG, W ;

MILLER, JR ;

LOVELACE, RE ;

HAYS, AP ;

KIM, TS .

NEUROLOGY, 1990, 40 (04) :595-599

[10] LYMPHOMA, MOTOR-NEURON DISEASES, AND AMYOTROPHIC-LATERAL-SCLEROSIS [J].

YOUNGER, DS ;

ROWLAND, LP ;

LATOV, N ;

HAYS, AP ;

LANGE, DJ ;

SHERMAN, W ;

INGHIRAMI, G ;

PESCE, MA ;

KNOWLES, DM ;

POWERS, J ;

MILLER, JR ;

FETELL, MR ;

LOVELACE, RE .

ANNALS OF NEUROLOGY, 1991, 29 (01) :78-86