ALCOHOL DRINKING IN RATS DURING AND FOLLOWING MORPHINE INJECTIONS

被引：48

作者：

VOLPICELLI, JR

ULM, RR

HOPSON, N

机构：

[1] UNIV PENN,DEPT PSYCHIAT,PHILADELPHIA,PA 19104

[2] UNIV PENN,DEPT PSYCHOL,PHILADELPHIA,PA 19104

[3] SALISBURY STATE COLL,DEPT PSYCHOL,SALISBURY,MD 21801

来源：

ALCOHOL | 1991年 / 8卷 / 04期

关键词：

MORPHINE; ALCOHOL; ALCOHOLISM; OPIOIDS; RATS;

D O I：

10.1016/0741-8329(91)90401-H

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Adult male Sprague-Dawley rats given daily SC injections of 2.5 mg/kg or 10 mg/kg morphine sulfate (for eight days) decreased preference for a 5% (v/v) ethanol solution, and then increased ethanol preference during the postinjection period, relative to a saline control group. These bidirectional effects were directly related to morphine dosage. The results were interpreted as supporting the theory that alcohol drinking is reinforced through its interaction with the endogenous opioid system and can compensate for deficiencies in opioid receptor activity.

引用

页码：289 / 292

页数：4

共 18 条

[1]

BAKER TB, 1986, NEBRASKA S MOTIVATIO, P257

[2]

CASEY A, 1960, Q J STUD ALCOHOL, V21, P208

[3] ATTENUATION OF ALCOHOL DRINKING IN TETRAHYDROISOQUINOLINE-TREATED RATS BY MORPHINE AND NALTREXONE [J].