AUTORADIOGRAPHIC ANALYSES OF THE EFFECTS OF ESTRADIOL BENZOATE ON [H-3] PAROXETINE BINDING IN THE CEREBRAL-CORTEX AND DORSAL HIPPOCAMPUS OF GONADECTOMIZED MALE AND FEMALE RATS

Effects of estradiol benzoate (EB) on [H-3]paroxetine binding in dorsal hippocampus and cerebral cortex of gonadectomized male and female rats were evaluated by quantitative autoradiography. EB significantly decreased [H-3]paroxetine binding in male and female rats in the oriens layers of CA1-CA4, and in the radiata/lacunosum moleculare layers of CA2 and CA3. Sex differences were also noted, with binding of [H-3]paroxetine being significantly lower in female rats in the radiata/lacunosum moleculare layers of CA2 and CA4, and in the suprapyramidal dentate. No significant effects of either EB or sex were noted in the cortex.