INTERACTION OF ETHANOL WITH HEMOGLOBIN - IMPLICATIONS FOR ALCOHOL-ABUSE

被引：3

作者：

TAIWO, FA

SYMONS, MCR

机构：

[1] Department of Chemistry, University of Leicester

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1993年 / 19卷 / 02期

关键词：

EPR; ETHANOL; HEMOGLOBIN; HYDROXYETHYL RADICAL;

D O I：

10.3109/10715769309056506

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ingestion of large amounts of ethanol results in a variety of toxicological consequences of which reduced oxygen supply is a marked respiratory effect. Experimentation involving the in-vivo administration of ethanol to rats, identifies the formation of ferri-haemoprotein species and hydroxyl radicals in the liver. Our work on the in-vitro effect of ethanol on oxyhaemoglobin shows the formation of ferri-haemoglobin and the alpha-hydroxyethyl radical as an intermediate. The impairment of oxygen transport efficiency of haemoglobin may be a result of its oxidation to the non-functional ferrihaemoglobin form.

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页码：121 / 124

页数：4

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