HOST-CELL ANTIGENIC PROFILE ACQUIRED BY HIV-1 IS A MARKER OF ITS CELLULAR-ORIGIN

被引：14

作者：

ABBATE, I

CAPOBIANCHI, MR

FAIS, S

CASTILLETTI, C

MERCURI, F

FEI, PC

AMEGLIO, F

DIANZANI, F

机构：

[1] UNIV ROMA LA SAPIENZA,INST VIROL,I-00185 ROME,ITALY

[2] INST SAN GALLICANO,ROME,ITALY

[3] IST SUPER SANITA,I-00161 ROME,ITALY

来源：

ARCHIVES OF VIROLOGY | 1995年 / 140卷 / 10期

关键词：

D O I：

10.1007/BF01384347

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-1 acquires cell membrane proteins during budding. The cell membrane proteins (CMP) profile of laboratory HIV-1 strains grown in different host cells was established, by using an immobilized antibody capture (IAC), to verify whether CMPs present on HIV-1 correlate with its host cell origin. HIV-1 grown in different cell lines incorporates cell markers such as CD3, CD19, CD14, CD31 and IL 2-R, according to the distinctive expression of these antigens on the host cells. Furthermore, also T-tropic and monocytotropic HIV-1 strains display host cell specific markers, supporting the hypothesis that virus associated CMPs are a marker of host cell origin.

引用

页码：1849 / 1854

页数：6

共 21 条

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