NEGATIVE REGULATION OF HUMAN INSULIN GENE-EXPRESSION BY THE 5'-FLANKING REGION IN NON-PANCREATIC CELLS

被引：23

作者：

TAKEDA, J

ISHII, S

SEINO, Y

IMAMOTO, F

IMURA, H

机构：

[1] KYOTO UNIV,SCH MED,DEPT INTERNAL MED 2,KYOTO 606,JAPAN

[2] TSUKUBA LIFE SCI CTR,INST PHYS & CHEM RES,MOLEC GENET LAB,IBARAKI,JAPAN

来源：

FEBS LETTERS | 1989年 / 247卷 / 01期

关键词：

D O I：

10.1016/0014-5793(89)81236-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：41 / 45

页数：5

共 23 条

[1] THE HIGHLY POLYMORPHIC REGION NEAR THE HUMAN INSULIN GENE IS COMPOSED OF SIMPLE TANDEMLY REPEATING SEQUENCES [J].

BELL, GI ;

SELBY, MJ ;

RUTTER, WJ .

NATURE, 1982, 295 (5844) :31-35

[2] A POLYMORPHIC LOCUS NEAR THE HUMAN INSULIN GENE IS ASSOCIATED WITH INSULIN-DEPENDENT DIABETES-MELLITUS [J].

BELL, GI ;

HORITA, S ;

KARAM, JH .

DIABETES, 1984, 33 (02) :176-183

[3] POLYMORPHIC DNA REGION ADJACENT TO THE 5'-END OF THE HUMAN INSULIN GENE [J].

BELL, GI ;

KARAM, JH ;

RUTTER, WJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09) :5759-5763

[4] CELL-SPECIFIC EXPRESSION OF THE RAT INSULIN GENE - EVIDENCE FOR ROLE OF 2 DISTINCT-5' FLANKING ELEMENTS [J].

EDLUND, T ;

WALKER, MD ;

BARR, PJ ;

RUTTER, WJ .

SCIENCE, 1985, 230 (4728) :912-916

[5] RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS [J].

GORMAN, CM ;

MOFFAT, LF ;

HOWARD, BH .

MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (09) :1044-1051

[6] HERITABLE FORMATION OF PANCREATIC BETA-CELL TUMORS IN TRANSGENIC MICE EXPRESSING RECOMBINANT INSULIN SIMIAN VIRUS-40 ONCOGENES [J].

HANAHAN, D .

NATURE, 1985, 315 (6015) :115-122

[7] MECHANISM OF GLUCOSE-INDUCED INSULIN-SECRETION [J].

HEDESKOV, CJ .

PHYSIOLOGICAL REVIEWS, 1980, 60 (02) :442-509

[8] A MUTATIONAL ANALYSIS OF THE INSULIN GENE-TRANSCRIPTION CONTROL REGION - EXPRESSION IN BETA-CELLS IS DEPENDENT ON 2 RELATED SEQUENCES WITHIN THE ENHANCER [J].

KARLSSON, O ;

EDLUND, T ;

MOSS, JB ;

RUTTER, WJ ;

WALKER, MD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (24) :8819-8823

[9]

LESLIE RDG, 1987, DIABETES ANN, V3, P39

[10] SYSTEMATIC BINDING ANALYSIS OF THE INSULIN GENE-TRANSCRIPTION CONTROL REGION - INSULIN AND IMMUNOGLOBULIN ENHANCERS UTILIZE SIMILAR TRANSACTIVATORS [J].

MOSS, LG ;

MOSS, JB ;

RUTTER, WJ .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (06) :2620-2627

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