REVERSAL OF RESISTANCE TO DOXORUBICIN WITH CEPHARANTHINE IN MURINE-P388 LEUKEMIA-CELLS

被引：21

作者：

FUJIMURA, T ^{[1
]}

SHIBATA, H ^{[1
]}

MAEKAWA, I ^{[1
]}

FURUSAWA, S ^{[1
]}

KAWAUCHI, H ^{[1
]}

SASAKI, K ^{[1
]}

TAKAYANAGI, Y ^{[1
]}

机构：

[1] TOHOKU COLL PHARMACEUT SCI,CANC RES INST,4-4-1 KOMATSUSHIMA,AOBA KU,SENDAI 981,JAPAN

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1990年 / 54卷 / 04期

关键词：

D O I：

10.1254/jjp.54.464

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cytotoxic effect in vitro and antitumor effect in vivo of doxorubicin (DOX) combined with cepharanthine were investigated on DOX-resistant murine P388 leukemia (P388/R) cells. Cepharanthine was minimally cytotoxic in the cell line, but reversed DOX-resistance in a dose-related manner in P388/R cells. The administration of cepharanthine to mice bearing the P388 leukemia enhanced the antitumor activity of DOX. These results indicate that cepharanthine is an effective agent to reverse DOX-resistant cells. © 1990, The Japanese Pharmacological Society. All rights reserved.

引用

页码：464 / 467

页数：4

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