IMAGING AND THERAPY WITH MONOCLONAL-ANTIBODIES IN NONHEMATOPOIETIC TUMORS

被引：56

作者：

MACH, JP ^{[1
]}

PELEGRIN, A ^{[1
]}

BUCHEGGER, F ^{[1
]}

机构：

[1] SWISS INST EXPTL CANC RES, CH-1066 EPALINGES, SWITZERLAND

来源：

CURRENT OPINION IN IMMUNOLOGY | 1991年 / 3卷 / 05期

关键词：

D O I：

10.1016/0952-7915(91)90097-K

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although radiolabelled monoclonal antibodies are useful in tumor imaging, in our opinion their most important role is in the evaluation of the capacity of newly developed monoclonal antibodies to localize in tumors specifically. Intravenous injections of monoclonal antibody fragments, labelled with beta-emitting radionuclides, can completely eradicate large human colon carcinoma xenografts in nude mice whereas this is not achieved by unconjugated monoclonal antibodies. New strategies are being developed to make radioimmunotherapy applicable to carcinoma patients.

引用

页码：685 / 693

页数：9

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