NITRITE FROM INFLAMMATORY CELLS - A CANCER RISK FACTOR IN ULCERATIVE-COLITIS

被引：53

作者：

ROEDIGER, WEW

LAWSON, MJ

RADCLIFFE, BC

机构：

[1] UNIV ADELAIDE,DEPT SURG,CELL PHYSIOL LAB,ADELAIDE,SA 5001,AUSTRALIA

[2] QUEEN ELIZABETH HOSP,DEPT GASTROENTEROL,WOODVILLE,SA 5011,AUSTRALIA

来源：

DISEASES OF THE COLON & RECTUM | 1990年 / 33卷 / 12期

关键词：

Cancer; Colon; N-nitroso compounds; Nitrites; Ulcerative colitis;

D O I：

10.1007/BF02139219

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Elevated levels of luminal nitrite and a lowered luminal pH were found in 77 percent of patients with acute ulcerative colitis. No luminal nitrite was found in healthy control subjects. Nitrites are a secretory product of activated macrophages and neutrophils of the lamina propria, whereas the lowered luminal pH is due to diminished bicarbonate formation by impaired colonocytes. A hypothesis is put forward that nitrites, lowered pH, and bacterial amines are conducive to formation of carcinogenic n-nitroso compounds, which reflect a cancer risk in patients with ulcerative colitis dependent on the type and extent of inflammatory cell activation as well as metabolic impairment of colonic epithelial cells. © 1990 American Society of Colon and Rectal Surgeons.

引用

页码：1034 / 1036

页数：3

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