CORONARY THROMBOLYSIS WITH RECOMBINANT TISSUE PLASMINOGEN-ACTIVATOR - INTRACORONARY VS INTRAVENOUS ADMINISTRATION

被引：11

作者：

GU, S

DUCAS, J

WOLFE, K

PATTON, JN

PREWITT, RM

机构：

[1] HLTH SCI CTR, DEPT MED CARDIOL, WINNIPEG R3E 0Z3, MANITOBA, CANADA

[2] UNIV MANITOBA, CARDIOL SECT, WINNIPEG R3T 2N2, MANITOBA, CANADA

来源：

CHEST | 1991年 / 100卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1378/chest.100.1.201

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

We employed a canine model of coronary thrombosis, induced by injection of radioactive blood clot, via a catheter placed in the left anterior descending coronary artery, to compare effects of recombinant tissue plasminogen activator (rtPA) administered intravenously and administered directly into the coronary circulation. A control group did not receive rtPA. Compared with controls, both rtPA regimens induced coronary thrombolysis. However, compared with intravenous administration, rate and extent of coronary thrombolysis were increased with intracoronary administration. Most likely, the enhanced thrombolysis with intracoronary administration is explained by an increase in delivery of the drug to the thrombus.

引用

页码：201 / 206

页数：6

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