GLUTAMINE SYNTHESIS IN STREPTOMYCES - A REVIEW

被引：11

作者：

FISHER, SH

机构：

[1] Department of Microbiology, Boston University School of Medicine, Boston

来源：

GENE | 1992年 / 115卷 / 1-2期

关键词：

GLUTAMATE DEHYDROGENASE; GLUTAMATE SYNTHASE; GLUTAMINE SYNTHETASE; NITROGEN REGULATION;

D O I：

10.1016/0378-1119(92)90534-V

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The synthesis of glutamine synthetase (GS), a key enzyme in ammonium (NH4+) assimilation, is regulated by nitrogen availability in several Streptomyces strains. In addition, the enzymatic activity of the GS enzyme is post-translationally regulated by adenylylation. Nitrogen regulation of GS synthesis is mediated at the transcriptional level in S. coelicolor, and transcription of the GS structural gene (glnA) requires a positive regulatory protein, GlnR. The amino acid sequence of the GlnR protein is similar to that of the Escherichia coli positive regulatory proteins, OmpR and PhoB, which belong to the family of bacterial two-component regulatory systems. DNA encoding a GSII-like enzyme has been cloned from S. viridochromogenes and S. hygroscopicus, but the role of this GS isoenzyme in NH4+ assimilation in Streptomyces is unclear.

引用

页码：13 / 17

页数：5

共 30 条

[1] IDENTIFICATION OF GENES AND GENE-PRODUCTS WHOSE EXPRESSION IS ACTIVATED DURING NITROGEN-LIMITED GROWTH IN BACILLUS-SUBTILIS [J].