SYNTHESIS OF 2,19-BRIDGED ANDROSTENEDIONES

被引：10

作者：

BURKHART, JP ^{[1
]}

HUBER, EW ^{[1
]}

LASKOVICS, FM ^{[1
]}

PEET, NP ^{[1
]}

机构：

[1] MARION MERRELL DOW RES INST,ORGAN CHEM,2110 E GALBRAITH RD,CINCINNATI,OH 45215

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 19期

关键词：

D O I：

10.1021/jo00045a028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of 2,19-(methyleneoxy)androst-4-ene-3,17-dione (4a), a potent, time-dependent inhibitor of human placental aromatase, and its thio (4b), amino (5), and methylene (14) analogs are described. The key step in the construction of 4a, 4b, and 5 is a Lewis acid-mediated intramolecular alkylation of an A-ring O-trimethylsilyl dienol ether.

引用

页码：5150 / 5154

页数：5

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