SEGREGATION ANALYSIS OF SPEECH AND LANGUAGE DISORDERS

被引：33

作者：

LEWIS, BA ^{[1
]}

COX, NJ ^{[1
]}

BYARD, PJ ^{[1
]}

机构：

[1] UNIV CHICAGO, DEPT MED, CHICAGO, IL 60637 USA

来源：

BEHAVIOR GENETICS | 1993年 / 23卷 / 03期

关键词：

SPEECH DISORDERS; LANGUAGE DISORDERS; SEGREGATION ANALYSIS; DEVELOPMENTAL DISORDERS; LEARNING DISABILITIES;

D O I：

10.1007/BF01082469

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Complex segregation analysis was performed on pedigrees ascertained through 45 probands (26 males, 19 females) with a history of preschool speech and language disorders. Hypotheses concerning mode of inheritance were tested using the POINTER segregation analysis program. Although there is strong evidence for familial transmission of this trait, we were unable to distinguish between a major gene and multifactorial transmission model using likelihood-ratio chi-square tests. Future studies with quantitative measures of speech and language disorders are needed to resolve the issue of mode of inheritance for this trait.

引用

页码：291 / 297

页数：7

共 31 条

[1] THE GENETIC-BACKGROUND OF DEVELOPMENTAL LANGUAGE-DISORDERS [J].