THE PENETRATION OF CIPROFLOXACIN INTO BRONCHIAL-MUCOSA, LUNG PARENCHYMA, AND PLEURAL TISSUE AFTER INTRAVENOUS ADMINISTRATION

被引：14

作者：

DAN, M

TOROSSIAN, K

WEISSBERG, D

KITZES, R

机构：

[1] EDITH WOLFSON MED CTR,DEPT THORAC SURG,IL-58100 HOLON,ISRAEL

[2] CARMEL HOSP,PHARMACOL UNIT,HAIFA,ISRAEL

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1993年 / 44卷 / 01期

关键词：

CIPROFLOXACIN; QUINOLONES; TISSUE PENETRATION; BRONCHIAL MUCOSA; LUNG PARENCHYMA; PLEURA;

D O I：

10.1007/BF00315290

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have studied the concentrations of ciprofloxacin in serum, bronchial mucosa, lung parenchyma, and pleural tissue after a single intravenous dose of 200 mg in 20 patients subjected to lung surgery. The concentrations of ciprofloxacin in the tissues exceeded that in the serum by 3-fold to 7-fold: serum 0.6 mug . ml -1, bronchial mucosa 1.9 mug . g-1, lung parenchyma 3.4 mug . g-, and pleural tissue 1.7 mug . g-1. The achievable concentrations of ciprofloxacin in the tissues of the lower respiratory tract are above the MICs for most lung pathogens.

引用

页码：101 / 102

页数：2

共 16 条

[1]

BALDWIN DR, 1990, ANTIMICROB AGENTS CH, V34, P1012

[2]

BARRE J, 1988, J ANTIMICROB CHEMOTH, V22, P299

[3] PENETRATION OF ANTIBIOTICS INTO THE RESPIRATORY TREE [J].