GENE-THERAPY - APPLICATIONS TO THE TREATMENT OF GASTROINTESTINAL AND LIVER-DISEASES

被引：48

作者：

CHANG, AGY ^{[1
]}

WU, GY ^{[1
]}

机构：

[1] UNIV CONNECTICUT, CTR HLTH,SCH MED,DEPT MED, DIV GASTROENTEROL HEPATOL,ROOM AM-044, FARMINGTON, CT 06030 USA

来源：

GASTROENTEROLOGY | 1994年 / 106卷 / 04期

关键词：

D O I：

10.1016/0016-5085(94)90771-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There has been much progress in our understanding of molecular mechanisms in the pathogenesis of inherited metabolic disorders. In addition, powerful new molecular techniques have made possible phenotypic alterations by delivery of foreign genes to target cells. As a result, concepts and methods that would have been considered purely science fiction 10 years ago can now be found in human clinical trials engaged in the treatment of these disorders. In this review, we have attempted to provide an introduction and survey of the topic of gene therapy, with specific examples of laboratory and clinical achievements to date, and highlights on potentials for applications in digestive diseases.

引用

收藏

页码：1076 / 1084

页数：9

相关论文

共 121 条

[1] GERMAN STATE UNEXPECTEDLY APPROVES 1ST GENE TRIALS [J].

ABBOTT, A .

NATURE, 1992, 360 (6406) :702-702

[2] TRANSDUCTION OF PRIMARY HUMAN HEPATOCYTES WITH AMPHOTROPIC AND XENOTROPIC RETROVIRAL VECTORS [J].

ADAMS, RM ;

SORIANO, HE ;

WANG, M ;

DARLINGTON, G ;

STEFFEN, D ;

LEDLEY, FD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) :8981-8985

[3]

ANDREASON GL, 1988, BIOTECHNIQUES, V6, P650

[4] EXPRESSION OF HUMAN FACTOR-IX IN RABBIT HEPATOCYTES BY RETROVIRUS-MEDIATED GENE-TRANSFER - POTENTIAL FOR GENE-THERAPY OF HEMOPHILIA-B [J].

ARMENTANO, D ;

THOMPSON, AR ;

DARLINGTON, G ;

WOO, SLC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) :6141-6145

[5] PROVOCATIVE GENE-THERAPY STRATEGY FOR THE TREATMENT OF HEPATOCELLULAR-CARCINOMA [J].

ASKARI, F ;

WILSON, J .

HEPATOLOGY, 1992, 16 (01) :273-274

[6] SUPPRESSION OF HUMAN COLORECTAL-CARCINOMA CELL-GROWTH BY WILD-TYPE-P53 [J].

BAKER, SJ ;

MARKOWITZ, S ;

FEARON, ER ;

WILLSON, JKV ;

VOGELSTEIN, B .

SCIENCE, 1990, 249 (4971) :912-915

[7] DIRECT INTRODUCTION OF GENES INTO RATS AND EXPRESSION OF THE GENES [J].

BENVENISTY, N ;

RESHEF, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (24) :9551-9555

[8]

Blaese R M, 1991, Allergol Immunopathol (Madr), V19, P25

[9] PROGRESS TOWARD GENE-THERAPY [J].

BLAESE, RM .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1991, 61 (02) :S47-S55

[10] TUMOR SUPPRESSION AFTER TUMOR-CELL TARGETED TUMOR-NECROSIS-FACTOR-ALPHA GENE-TRANSFER [J].

BLANKENSTEIN, T ;

QIN, ZH ;

UBERLA, K ;

MULLER, W ;

ROSEN, H ;

VOLK, HD ;

DIAMANTSTEIN, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (05) :1047-1052

← 1 2 3 4 5 6 7 8 9 10 →