ALPHAVIRUS EXPRESSION SYSTEMS - APPLICATIONS TO MOSQUITO VECTOR STUDIES

被引：34

作者：

HIGGS, S

POWERS, AM

OLSON, KE

机构：

[1] Ar-thropodbome and Infectious Diseases Laboratory, Department of Microbiology, Colorado State University, Fort Collins, CO 80523, Foothills Campus

来源：

PARASITOLOGY TODAY | 1993年 / 9卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0169-4758(93)90098-Z

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In this review, Steve Higgs, Ann Powers and Ken Olson describe how alphavirus expression systems, based on infectious cDNA clones of Sindbis virus, constitute a novel RNA virus delivery system suitable for the efficient expression of heterologous gene products or RNA sequences in mosquito cells or adult mosquitoes. The technique permits ready assessment of molecular genetic-based methods of intracellular interference to infection and provides a powerful new tool for molecular biological studies in arthropods.

引用

页码：444 / 452

页数：9

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