PROTECTION OF PRIMATES AGAINST SOMAN POISONING BY PRETREATMENT WITH PYRIDOSTIGMINE

被引：192

作者：

DIRNHUBER, P ^{[1
]}

FRENCH, MC ^{[1
]}

GREEN, DM ^{[1
]}

LEADBEATER, L ^{[1
]}

STRATTON, JA ^{[1
]}

机构：

[1] MINIST DEF,CHEM DEF ESTAB,PORTON DOWN,SALISBURY SP4 0JQ,WILTSHIRE,ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1979年 / 31卷 / 05期

关键词：

D O I：

10.1111/j.2042-7158.1979.tb13504.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. Pretreatment with the maximum sign‐free dose (200 μg kg−1, i.v.) raised the subcutaneous LD50 of soman by a factor of 28 in rhesus monkeys and 15 in marmosets. Theprotection afforded by a quarter of the sign‐free dose of pyridostigmine was not significantly less. These levels of protection are higher than any reported in non‐primate species. 1979 Royal Pharmaceutical Society of Great Britain

引用

页码：295 / 299

页数：5

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