ANDROGEN RECEPTORS IN THE RAT-BRAIN, ANTERIOR-PITUITARY GLAND AND VENTRAL PROSTATE-GLAND - EFFECTS OF ORCHIDECTOMY AND AGING

被引：45

作者：

GREENSTEIN, BD ^{[1
]}

机构：

[1] UNIV LONDON CHELSEA COLL SCI & TECHNOL,DEPT PHARMACOL,LONDON SW3 6LX,ENGLAND

来源：

JOURNAL OF ENDOCRINOLOGY | 1979年 / 81卷 / 01期

关键词：

D O I：

10.1677/joe.0.0810075

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Available high-affinity binding sites for 5α-dihydrotestosterone (DHT) were measured in cytosols obtained from the amygdala, hypothalamus, anterior pituitary gland and ventral prostate gland of 12-week-old rats at various times after orchidectomy, and in the corresponding tissues of 18-month-old male rats. It is suggested that the lower affinity of the DHT bindig reaction in brain and ventral prostatic cytosols after orchidectomy or ageing respectively, may explain, at least in part, the changes in the responsiveness of the tissues to androgens.

引用

页码：75 / 81

页数：7

共 20 条

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