CONTROL OF THE ENANTIOMERIC PURITY OF N-BOC N-METHYLAMINO ACID BUILDING-BLOCKS BY A CONVENIENT NMR METHOD

被引：6

作者：

CALMES, M

DAUNIS, J

ELYACOUBI, R

JACQUIER, R

机构：

[1] Laboratoire de synthèse et d't́udes physicochimiques d'aminoacides, peptides. URA 468 - Université de Montepellier II -, 34095 MONTPELLIER Cedex 5, Place E.Bataillon

来源：

TETRAHEDRON-ASYMMETRY | 1990年 / 1卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(00)86324-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantiomeric purity of N-Boc N-methylamino acid methyl esters could be easily and accurately established by measuring at 250 MHz in presence of Eu(hfc)3 the enantiomeric shift separation of N-Boc and/or N-methyl signals of one of the conformers. © 1990.

引用

页码：329 / 334

页数：6

共 20 条

[1] BARRETT GC, 1985, CHEM BIOCH AMINO ACI, P11
[2] A GENERAL AND ACCURATE NMR DETERMINATION OF THE ENANTIOMERIC PURITY OF ALPHA-AMINO-ACIDS AND ALPHA-AMINO-ACID DERIVATIVES
CALMES, M
DAUNIS, J
JACQUIER, R
VERDUCCI, J
[J]. TETRAHEDRON, 1987, 43 (10) : 2285 - 2292
[3] N-METHYLAMINO ACIDS IN PEPTIDE-SYNTHESIS .6. METHOD FOR DETERMINING ENANTIOMERIC PURITY OF N-METHYLAMINO ACIDS AND THEIR DERIVATIVES BY ION-EXCHANGE CHROMATOGRAPHY AS THEIR C-TERMINAL LYSYL DIPEPTIDES
CHEUNG, ST
BENOITON, NL
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1977, 55 (05): : 911 - 915
[4] N-METHYLAMINO ACIDS IN PEPTIDE-SYNTHESIS .5. SYNTHESIS OF N-TERT-BUTYLOXYCARBONYL, N-METHYLAMINO ACIDS BY N-METHYLATION
CHEUNG, ST
BENOITON, NL
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1977, 55 (05): : 906 - 910
[5] N-METHYLAMINO ACIDS IN PEPTIDE-SYNTHESIS .7. STUDIES ON ENANTIOMERIC PURITY OF N-METHYLAMINO ACIDS PREPARED BY VARIOUS PROCEDURES
CHEUNG, ST
BENOITON, NL
[J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1977, 55 (05): : 916 - 921
[6] DETERMINATION OF N-METHYLAMINO ACIDS AND THEIR OPTICAL PURITY WITH AN AMINO ACID ANALYZER
COGGINS, JR
BENOITON, NL
[J]. JOURNAL OF CHROMATOGRAPHY, 1970, 52 (02): : 251 - &
[7] SYNTHESIS OF N-METHYLAMINO ACID DERIVATIVES FROM AMINO ACID DERIVATIVES USING SODIUM HYDRIDE/METHYL IODIDE
COGGINS, JR
BENOITON, NL
[J]. CANADIAN JOURNAL OF CHEMISTRY, 1971, 49 (11): : 1968 - &
[8] SYNTHESIS OF (MEALA)TANDEM, THE BIS(N-METHYLALANINE) ANALOG OF DES-N-TETRAMETHYLTRIOSTIN-A
DHAON, MK
OLSEN, RK
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (17) : 3436 - 3440
[9] TRIFLUOROMETHANESULFONATES OF ALPHA-HYDROXYCARBOXYLATES - EDUCTS FOR THE RACEMIZATION - FREE SYNTHESIS OF N-SUBSTITUTED ALPHA-AMINO-ACIDS
EFFENBERGER, F
BURKARD, U
WILLFAHRT, J
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1983, 22 (01): : 65 - 66
[10] SYNTHESIS OF 9-FLUORENYLMETHYLOXYCARBONYL-PROTECTED N-ALKYL AMINO-ACIDS BY REDUCTION OF OXAZOLIDINONES
FREIDINGER, RM
HINKLE, JS
PERLOW, DS
ARISON, BH
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (01) : 77 - 81

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