GLYCOLIPIDS AS HOST-RESISTANCE STIMULATORS

被引：7

作者：

PONPIPOM, MM

HAGMANN, WK

OGRADY, LA

JACKSON, JJ

WOOD, DD

ZWEERINK, HJ

机构：

[1] Merck Sharp & Dohme Research Laboratories, Rahway

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 33卷 / 02期

关键词：

D O I：

10.1021/jm00164a062

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

6-(5-Cholesten-3β-yloxy)hexyl 1-thio-β-D-mannopyranoside (L-644,257) enhances natural host resistance in cyclo phosphamide-treated mice against Pseudomonas aeruginosa in a dose-dependent manner. It is active sc, im, and ip but not orally. L-644,257 is substantially more protective against P. aeruginosa than its α anomer. The β-L-fucose glycolipid is more effective when given im and ip than sc. The lactose and β-D-glucose glycolipids were only marginally effective to nonprotective. The 17β-steroidal side chain of L-644,257 can be modified without substantial loss of protective activity. © 1990, American Chemical Society. All rights reserved.

引用

页码：861 / 867

页数：7

共 41 条

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