COMPARATIVE METABOLISM OF CODEINE IN MAN, RAT, DOG, GUINEA-PIG AND RABBIT - IDENTIFICATION OF 4 NEW METABOLITES

被引：17

作者：

CONE, EJ

DARWIN, WD

GORODETZKY, CW

机构：

[1] National Institute on Drug Abuse, Division of Research, Addiction Research Centre, Lexington, Kentucky

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1979年 / 31卷 / 05期

关键词：

D O I：

10.1111/j.2042-7158.1979.tb13507.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The metabolism and excretion of codeine and its metabolites in untreated urine of man, rat, dog, guinea pig and rabbit were studied. Metabolites were identified by gas chromatography mass spectrometry operated in the chemical ionization mode (methane). Concentrations of codeine and metabolites were measured by selected ion monitoring. Codeine and norcodeine were found in the urine of all species but a new metabolite, hydrocodone, was found only in the urine from man, guinea pig and dog. Additional metabolites (presumably resulting from the metabolism of hydrocodone) were found in man and guinea pig. Overall recoveries of drug and metabolites from untreated urine were low for all species.

引用

页码：314 / 317

页数：4