CHANGES IN ANTIBODY PROFILE AFTER TREATMENT OF HUMAN ONCHOCERCIASIS

被引:11
作者
LEE, SJ
FRANCIS, HL
AWADZI, K
OTTESEN, EA
NUTMAN, TB
机构
[1] NIAID, PARASIT DIS LAB,BLDG 4,ROOM 126, 9000 ROCKVILLE PIKE, BETHESDA, MD 20892 USA
[2] ONCHOCERCIASIS CHEMOTHERAPEUT RES CTR, TAMALE, GHANA
关键词
D O I
10.1093/infdis/162.2.529
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To define the changes in antibody response to Onchocerca volvulus antigens after treatment of patients with onchocerciasis, IgG and IgE antibodies were examined quantitatively and qualitatively in 21 patients and 3 control individuals before and sequentially for 14 days after treatment with diethylcarbamazine. The quantitative levels of IgE and IgG responses (both polyclonal and O. volvulus-specific) remained essentially unchanged for all patients, but 9 of the 21 patients showed intensified responses to one or more parasite-specific antigens, and 8 of 21 developed antibodies to previously undetected antigens. There was a significant correlation between the intensities of infection and the development of newly recognized anti-O. volvulus antibodies. These studies demonstrate that O. volvulus-specific IgE and IgG antibody responses are, at least transiently, enhanced by treatment with diethylcarbamazine and that after treatment, parasites possibly release antigens previously hidden from the host's immune response. © 1990, by The University of Chicago.
引用
收藏
页码:529 / 533
页数:5
相关论文
共 33 条
[1]  
AKIYAMA T, 1981, Journal of Dermatology (Tokyo), V8, P43
[2]  
ANDERSON RI, 1973, Z TROPENMED PARASIT, V24, P447
[3]   BIOCHEMICAL AND IMMUNOCHEMICAL CHARACTERIZATION OF A 20-KILODALTON COMPLEX OF SURFACE-ASSOCIATED ANTIGENS FROM ADULT ONCHOCERCA-GUTTUROSA FILARIAL NEMATODES [J].
BRADLEY, JE ;
GREGORY, WF ;
BIANCO, AE ;
MAIZELS, RM .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 34 (03) :197-208
[4]   DANGEROUS REACTIONS TO TREATMENT OF ONCHOCERCIASIS WITH DIETHYLCARBAMAZINE [J].
BRYCESON, ADM ;
WARRELL, DA ;
POPE, HM .
BRITISH MEDICAL JOURNAL, 1977, 1 (6063) :742-744
[5]  
BUCK AA, 1973, Z TROPENMED PARASIT, V24, P21
[6]  
BUCK AA, 1974, ONCHOCERCIASIS SYMPT, P20
[7]  
BUTTNER DW, 1982, TROPENMED PARASITOL, V33, P201
[8]   LITOMOSOIDES-CARINII INFECTION IN COTTON-RATS BEFORE AND AFTER TREATMENT WITH DIETHYLCARBAMAZINE AND SURAMIN - EVOLUTION OF FREE SERUM ANTIGENS [J].
CARME, B ;
RICHARDLENOBLE, D ;
AMGAR, A ;
DANIS, M ;
GENTILINI, M .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1982, 76 (04) :454-457
[9]   ONCHOCERCA-GIBSONI - INCREASE OF CIRCULATING EGG ANTIGEN WITH CHEMOTHERAPY IN BOVINES [J].
FORSYTH, KP ;
MITCHELL, GF ;
COPEMAN, DB .
EXPERIMENTAL PARASITOLOGY, 1984, 58 (01) :41-55
[10]   THE MAZZOTTI REACTION FOLLOWING TREATMENT OF ONCHOCERCIASIS WITH DIETHYLCARBAMAZINE - CLINICAL SEVERITY AS A FUNCTION OF INFECTION INTENSITY [J].
FRANCIS, H ;
AWADZI, K ;
OTTESEN, EA .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1985, 34 (03) :529-536