EFFECTS OF THE PROSTAGLANDIN ANALOG MISOPROSTOL ON INFLAMMATORY MEDIATOR RELEASE BY HUMAN MONOCYTES

被引：16

作者：

WIDOMSKI, DL ^{[1
]}

WALSH, RE ^{[1
]}

BARON, DA ^{[1
]}

HIDVEGI, MI ^{[1
]}

FRETLAND, DJ ^{[1
]}

COLLINS, PW ^{[1
]}

GAGINELLA, TS ^{[1
]}

机构：

[1] SEARLE RES & DEV,GASTROINTESTINAL DIS RES & PATHOL,SKOKIE,IL 60077

来源：

AGENTS AND ACTIONS | 1991年 / 34卷 / 1-2期

关键词：

D O I：

10.1007/BF01993229

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effect of misoprostol (M) on IL-1-beta, TNF-alpha, and lipid mediator release (assessed by RIA) by adherent (assessed by electron microscopy) human monocytes were studied in vitro. Human monocytes stimulated with E. Coli-derived lipopolysaccharide showed an increase in both IL-1-beta and TNF-alpha release. Incubation of the monocytes with LPS and M (18 hrs.), resulted in a reduction of both IL-1-beta and TNF-alpha levels. Leukotriene B4 levels did not increase in response to LPS or M. LPS also caused an increase in thromboxane (TXB2). M decreased TXB2 levels. 6-keto PGF1-alpha (6KP). Incubation with LPS and M stimulated release. LPS caused an increase in PGE2 levels. M (100-mu-M) caused an increase in PGE2 levels, M (1-mu-M) had no effect on PGE2. These data suggest a possible immunomodulatory role for misoprostol in inflammatory diseases.

引用

页码：30 / 31

页数：2

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