ATRIAL-NATRIURETIC-FACTOR (ANF) INHIBITS THYROID-HORMONE SECRETION IN THE MOUSE

被引：13

作者：

AHREN, B ^{[1
]}

机构：

[1] UNIV LUND,DEPT SURG,S-22362 LUND,SWEDEN

来源：

LIFE SCIENCES | 1990年 / 47卷 / 21期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0024-3205(90)90410-S

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Recently, thyroid follicular cells were shown to exhibit atrial natriuretic factor (ANF)-like immunoreactivity and high affinity ANF receptors. In this study, we therefore examined the effects of synthetic rat ANF1-28 on basal and stimulated thyroid hormone secretion in the mouse, according to the McKenzie technique. Iodine deficient mice were pretreated with 125I and thyroxine. ANF (3 nmol/animal) was found to inhibit the increase in blood radioiodine levels that was induced by TSH or vasoactive intestinal polypeptide (VIP). Furthermore, ANF and norepinephrine additively inhibited the TSH-induced increase in blood radioiodine levels. It is concluded that ANF inhibits thyroid hormone secretion, which, therefore, might be locally regulated by intrathyroidal ANF. © 1990.

引用

页码：1973 / 1977

页数：5

共 21 条

[1] ANF INHIBITS GLUCOSE-STIMULATED INSULIN-SECRETION IN MOUSE AND RAT [J].