SYNERGISTIC INTERACTION OF CYCLOSPORINE-A AND VERAPAMIL ON VINCRISTINE AND DAUNORUBICIN RESISTANCE IN MULTIDRUG-RESISTANT HUMAN LEUKEMIA-CELLS INVITRO

被引：28

作者：

OSANN, K ^{[1
]}

SWEET, P ^{[1
]}

SLATER, LM ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,COLL MED,DEPT MED,IRVINE,CA 92717

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1992年 / 30卷 / 02期

关键词：

CYCLOSPORINE-A; VERAPAMIL SYNERGY;

D O I：

10.1007/BF00686409

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We studied the effects of cyclosporin A and verapamil on the modulation of vincristine and daunorubicin resistance in a multidrug-resistant subline of human T-cell acute lymphatic leukemia GM3639. Our results show that cyclosporin A is more effective than verapamil as a modulator of the high degree of primary vincristine resistance and the low degree of daunorubicin cross-resistance expressed by this cell line. Isobologram analysis revealed that the combined modulators act synergistically in correcting both vincristine and daunorubicin resistance.

引用

页码：152 / 154

页数：3

共 15 条

[1] CYCLOSPORINE-A AND VERAPAMIL HAVE DIFFERENT EFFECTS ON ENERGY-METABOLISM IN MULTIDRUG-RESISTANT TUMOR-CELLS [J].