PHOSPHOLIPID IMPORT INTO MITOCHONDRIA - POSSIBLE REGULATION MEDIATED THROUGH LIPID POLYMORPHISM

被引：7

作者：

ARDAIL, D ^{[1
]}

LERME, F ^{[1
]}

LOUISOT, P ^{[1
]}

机构：

[1] LYON SUD MED SCH,DEPT BIOCHEM,CNRS,U189,INSERM,BP 12,F-69921 OULLINS,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(05)81559-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously demonstrated that the translocation of microsomal phosphatidylserine to the inner mitochondrial membrane occurs via contact sites before decarboxylation. According to the specific lipid composition of contact sites, we investigated lipid polymorphism as a possible regulation mechanism of phospholipid import into mitochondria. Phosphatidylserine import into mitochondria is increased in the presence of calcium, under conditions where non bilayer lipid-structures can be induced in cardiolipincontaining membranes. The results are discussed in terms of structural as well as functional domains heterogeneity within contact sites. © 1992 Academic Press, Inc.

引用

页码：1384 / 1390

页数：7

共 22 条

[1]

ARDAIL D, 1990, J BIOL CHEM, V265, P18797

[2]

ARDAIL D, 1991, J BIOL CHEM, V266, P7978

[3] CHARACTERIZATION OF THE SUBMITOCHONDRIAL COMPARTMENTS - STUDY OF THE SITE OF SYNTHESIS OF DOLICHOL AND DOLICHOL-LINKED SUGARS [J].

ARDAIL, D ;

LOUISOT, P ;

LEVRAT, C .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (03) :1009-1017

[4] TRANSFER OF PHOSPHATIDIC-ACID BETWEEN MICROSOMAL AND MITOCHONDRIAL OUTER AND INNER MEMBRANES [J].

BARANSKA, J ;

WOJTCZAK, L .

BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 773 (01) :23-31

[5]

BARTLETT GR, 1959, J BIOL CHEM, V234, P466

[6] CONTACT SITES BETWEEN MITOCHONDRIAL ENVELOPE MEMBRANES - STRUCTURE AND FUNCTION IN ENERGY-TRANSFER AND PROTEIN-TRANSFER [J].

BRDICZKA, D .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1071 (03) :291-312

[7] THE MITOCHONDRIAL PHOSPHATE CARRIER RECONSTITUTED IN LIPOSOMES IS INHIBITED BY DOXORUBICIN [J].

CHENEVAL, D ;

MULLER, M ;

CARAFOLI, E .

FEBS LETTERS, 1983, 159 (1-2) :123-126

[8]

FOLCH J, 1957, J BIOL CHEM, V226, P497

[9] STRUCTURE OF THE ADRIAMYCIN-CARDIOLIPIN COMPLEX - ROLE IN MITOCHONDRIAL TOXICITY [J].

GOORMAGHTIGH, E ;

HUART, P ;

PRAET, M ;

BRASSEUR, R ;

RUYSSCHAERT, JM .

BIOPHYSICAL CHEMISTRY, 1990, 35 (2-3) :247-257

[10] CHEMICAL AND PHYSICAL FIXATION OF ISOLATED MITOCHONDRIA IN LOW-ENERGY AND HIGH-ENERGY STATES [J].

HACKENBR.CR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 61 (02) :598-+

← 1 2 3 →