TREATING PERIODONTAL-DISEASES BY BLOCKING TISSUE-DESTRUCTIVE ENZYMES

被引：60

作者：

GOLUB, LM

WOLFF, M

ROBERTS, S

LEE, HM

LEUNG, M

PAYONK, GS

机构：

[1] SUNY STONY BROOK,SCH DENT MED,DEPT RESTORAT DENT,STONY BROOK,NY 11794

[2] SUNY STONY BROOK,SCH DENT MED,DEPT ORAL & MAXILLOFACIAL SURG,STONY BROOK,NY 11794

[3] SUNY STONY BROOK,SCH DENT MED,DEPT ORAL BIOL & PATHOL,STONY BROOK,NY 11794

来源：

JOURNAL OF THE AMERICAN DENTAL ASSOCIATION | 1994年 / 125卷 / 02期

关键词：

D O I：

10.14219/jada.archive.1994.0261

中图分类号：

R78 [口腔科学];

学科分类号：

1003 [口腔医学];

摘要：

A new therapeutic approach involves the discovery by the ''Stony Brook group,'' that tetracyclines, but not other antibiotics, can inhibit host-derived collagen-destructive enzymes. This newly discovered property of tetracyclines is unrelated to the antimicrobial activity of these drugs. Examples support the hypothesis that this unexpected property of tetracyclines provides a new approach to treating periodontal diseases as well as a variety of medical disorders.

引用

收藏

页码：163 / 169

页数：7

相关论文

共 33 条

[1]

TETRACYCLINE AND ITS DERIVATIVES STRONGLY BIND TO AND ARE RELEASED FROM THE TOOTH SURFACE IN ACTIVE FORM [J].

BAKER, PJ ;

EVANS, RT ;

COBURN, RA ;

GENCO, RJ .

JOURNAL OF PERIODONTOLOGY, 1983, 54 (10) :580-585

[2]

MATRIX METALLOPROTEINASES - A REVIEW [J].

BIRKEDALHANSEN, H ;

MOORE, WGI ;

BODDEN, MK ;

WINDSOR, LJ ;

BIRKEDALHANSEN, B ;

DECARLO, A ;

ENGLER, JA .

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1993, 4 (02) :197-250

[3]

BOUWSMA O, 1992, J DENT RES, P71

[4]

BURNS FR, 1989, INVEST OPHTH VIS SCI, V30, P1569

[5]

AN EVALUATION OF MINOCYCLINE IN PATIENTS WITH PERIODONTAL-DISEASE [J].

CIANCIO, SG ;

MATHER, ML ;

MCMULLEN, JA .

JOURNAL OF PERIODONTOLOGY, 1980, 51 (09) :530-534

[6]

Golub L M, 1992, Curr Opin Dent, V2, P80

[7]

A NON-ANTIBACTERIAL CHEMICALLY-MODIFIED TETRACYCLINE INHIBITS MAMMALIAN COLLAGENASE ACTIVITY [J].

GOLUB, LM ;

MCNAMARA, TF ;

DANGELO, G ;

GREENWALD, RA ;

RAMAMURTHY, NS .

JOURNAL OF DENTAL RESEARCH, 1987, 66 (08) :1310-1314

[8]

FURTHER EVIDENCE THAT TETRACYCLINES INHIBIT COLLAGENASE ACTIVITY IN HUMAN CREVICULAR FLUID AND FROM OTHER MAMMALIAN SOURCES [J].

GOLUB, LM ;

WOLFF, M ;

LEE, HM ;

MCNAMARA, TF ;

RAMAMURTHY, NS ;

ZAMBON, J ;

CIANCIO, S .

JOURNAL OF PERIODONTAL RESEARCH, 1985, 20 (01) :12-23

[9]

LOW-DOSE DOXYCYCLINE THERAPY - EFFECT ON GINGIVAL AND CREVICULAR FLUID COLLAGENASE ACTIVITY IN HUMANS [J].

GOLUB, LM ;

CIANCIO, S ;

RAMAMURTHY, NS ;

LEUNG, M ;

MCNAMARA, TF .

JOURNAL OF PERIODONTAL RESEARCH, 1990, 25 (06) :321-330

[10]

MINOCYCLINE REDUCES GINGIVAL COLLAGENOLYTIC ACTIVITY DURING DIABETES - PRELIMINARY-OBSERVATIONS AND A PROPOSED NEW MECHANISM OF ACTION [J].

GOLUB, LM ;

LEE, HM ;

LEHRER, G ;

NEMIROFF, A ;

MCNAMARA, TF ;

KAPLAN, R ;

RAMAMURTHY, NS .

JOURNAL OF PERIODONTAL RESEARCH, 1983, 18 (05) :516-526

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