CATALEPSY INDUCED BY STRIATAL ACETYLCHOLINESTERASE INHIBITION WITH FASCICULIN IN RATS

被引：10

作者：

CASTELLO, ME ^{[1
]}

BOLIOLI, B ^{[1
]}

DAJAS, F ^{[1
]}

机构：

[1] INST INVEST BIOL CLEMENTE ESTABLE,DIV NEUROQUIM,AV ITALIA 3318,MONTEVIDEO 11600,URUGUAY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 41卷 / 03期

关键词：

CATALEPSY; BASAL GANGLIA; FASCICULIN; CHOLINERGIC; TOXIN; HALOPERIDOL; HVA;

D O I：

10.1016/0091-3057(92)90371-L

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The acetylcholinesterase inhibitor peptide fasciculin (FAS) was bilaterally injected into the striatum of rats. Twenty-four hours after injection, animals showed a cataleptic syndrome that was potentiated by haloperidol (HAL). The catalepsy was significantly decreased by IP atropine. Biochemically, only an increase of the homovanillic acid in the striatum was found 24 h and 7 days after FAS treatment. Seven days after the intrastriatal FAS injection, there was no HAL potentiation of catalepsy, which was even lower than that of rats treated with IP HAL after intrastriatal injection of saline. Results are interpreted as showing the central role of the cholinergic system in the induction of catalepsy in the rat.

引用

页码：547 / 550

页数：4

共 23 条

[1] EFFECTS OF LOCAL INHIBITION OF LOCUS COERULEUS ACETYLCHOLINESTERASE BY FASCICULIN IN RATS [J].

ABO, V ;

VIERA, L ;

SILVEIRA, R ;

DAJAS, F .

NEUROSCIENCE LETTERS, 1989, 98 (03) :253-257

[2]

BARTHOLINI G, 1987, NEUROTRANSMITTER INT, P1

[3] NEUROCHEMICAL AND BEHAVIORAL-CORRELATES OF UNILATERAL STRIATAL ACETYLCHOLINESTERASE INHIBITION BY FASCICULIN IN RATS [J].

BOLIOLI, B ;

CASTELLO, ME ;

JERUSALINSKY, D ;

RUBINSTEIN, M ;

MEDINA, J ;

DAJAS, F .

BRAIN RESEARCH, 1989, 504 (01) :1-6

[4]

BOLIOLI B, 1989, BRAIN RES, V27, P833

[5]

CERVENANSKY C, 1989, TOXICON, V27, P833

[6] CATALEPSY AND CIRCLING BEHAVIOR AFTER INTRACEREBRAL INJECTIONS OF NEUROLEPTIC, CHOLINERGIC AND ANTICHOLINERGIC AGENTS INTO CAUDATE-PUTAMEN, GLOBUS PALLIDUS AND SUBSTANTIA NIGRA OF RAT-BRAIN [J].

COSTALL, B ;

NAYLOR, RJ ;

OLLEY, JE .

NEUROPHARMACOLOGY, 1972, 11 (05) :645-+

[7] CHOLINERGIC-INDUCED AND NEUROLEPTIC-INDUCED CATALEPSY - MODIFICATION BY LESIONS IN CAUDATE-PUTAMEN [J].

COSTALL, B ;

OLLEY, JE .

NEUROPHARMACOLOGY, 1971, 10 (03) :297-&

[8] CATALEPSY AND CATATONIA AND PREDICTABILITY OF CATALEPSY TEST FOR NEUROLEPTIC ACTIVITY [J].

COSTALL, B ;

NAYLOR, RJ .

PSYCHOPHARMACOLOGIA, 1974, 34 (03) :233-241

[9] RAT STRIATAL ACETYLCHOLINESTERASE INHIBITION BY FASCICULIN (A POLYPEPTIDE FROM GREEN MAMBA SNAKE-VENOM) [J].

DAJAS, F ;

BOLIOLI, B ;

CASTELLO, ME ;

SILVEIRA, R .

NEUROSCIENCE LETTERS, 1987, 77 (01) :87-91

[10] ACETYLCHOLINESTERASE MAY HAVE NOVEL FUNCTIONS IN THE BRAIN [J].

GREENFIELD, S .

TRENDS IN NEUROSCIENCES, 1984, 7 (10) :364-368

← 1 2 3 →