LIPASE-CATALYZED AMINOLYSIS AND AMMONOLYSIS OF BETA-KETOESTERS - SYNTHESIS OF OPTICALLY-ACTIVE BETA-KETOAMIDES

被引：50

作者：

GARCIA, MJ ^{[1
]}

REBOLLEDO, F ^{[1
]}

GOTOR, V ^{[1
]}

机构：

[1] UNIV OVIEDO,FAC QUIM,DEPT QUIM ORGAN & INORGAN,E-33071 OVIEDO,SPAIN

来源：

TETRAHEDRON | 1994年 / 50卷 / 23期

关键词：

D O I：

10.1016/S0040-4020(01)81346-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aminolysis and ammonolysis reactions of beta-ketoesters catalyzed by Candida antarctica lipase ar e very efficient methods for the preparation of beta-ketoamides. When racemic amines are used in these precesses, the corresponding optically active beta-ketoamides are obtained with moderate-high enantiomeric excesses.

引用

页码：6935 / 6940

页数：6

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