THE IRS-1 SIGNALING SYSTEM

被引：297

作者：

MYERS, MG ^{[1
]}

SUN, XJ ^{[1
]}

WHITE, MF ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,PROGRAM CELL & DEV BIOL,BOSTON,MA 02215

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 07期

关键词：

D O I：

10.1016/0968-0004(94)90007-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin-receptor substrate 1 (IRS-1) is a principal substrate of the receptor tyrosine kinase for insulin and insulin-like growth factor 1, and a substrate for a tyrosine kinase activated by interleukin 4. IRS-1 undergoes multisite tyrosine phosphorylation and mediates downstream signals by 'docking' various proteins that contain Src homology 2 domains. IRS-1 appears to be a unique molecule; however, 4PS, a protein found mainly in hemopoietic cells, may represent another member of this family.

引用

页码：289 / 293

页数：5

共 42 条

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