CLONING AND CHROMOSOMAL LOCALIZATION OF THE GENE CODING FOR HUMAN PROTEIN-KINASE CK1

被引：34

作者：

TAPIA, C

FEATHERSTONE, T

GOMEZ, C

TAILLONMILLER, P

ALLENDE, CC

ALLENDE, JE

机构：

[1] UNIV CHILE, FAC MED, DEPT BIOQUIM, SANTIAGO 7, CHILE

[2] WASHINGTON UNIV, SCH MED, DEPT GENET, ST LOUIS, MO 63110 USA

[3] UNIV CHILE, FAC CIENCIAS, DEPT BIOL, SANTIAGO, CHILE

来源：

FEBS LETTERS | 1994年 / 349卷 / 02期

关键词：

CASEIN KINASE 1; CHROMOSOME; 13; PROTEIN KINASE; GENE MAPPING; FLUORESCENT IN SITU HYBRIDIZATION;

D O I：

10.1016/0014-5793(94)00679-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA clone coding for human protein kinase CK1 (casein kinase 1) has been isolated and sequenced demonstrating that it corresponds to a homolog of the CK1 alpha form found in bovine brain. The derived amino acid sequence of the human CK1 alpha. is identical to the bovine counterpart except that it contains 12 extra amino acids at the carboxyl end. Using this cDNA sequence and PCR amplification, YAC genomic clones that contain this human CK1 alpha sequence have been isolated. These YACs have been used for fluorescent in situ hybridization in order to localize the human CK1 alpha gene to chromosome 13q13.

引用

页码：307 / 312

页数：6

共 27 条

[1] A 3.5 GENOME EQUIVALENT MULTIACCESS YAC LIBRARY - CONSTRUCTION, CHARACTERIZATION, SCREENING AND STORAGE [J].