DISTRIBUTION OF 7-METHYLGUANINE AND OF REPLICATION SITES IN DIFFERENT KINETIC CLASSES OF DNA FROM RATS TREATED WITH DIMETHYLNITROSAMINE

被引：10

作者：

GALBRAITH, AI

CHAPLEO, MR

ITZHAKI, RF

机构：

[1] Paterson Laboratories, Christie Hospital, Holt Radium Institute

来源：

NUCLEIC ACIDS RESEARCH | 1978年 / 5卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/nar/5.9.3357

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The distribution of 7-methylguanine in the families of repetitive and unique sequesces of rat liver chromatin DNA has been studied using the technique of DNA-DNA reassociation. Rats were injected with di [14C] nitrosamine and chromatin DNA was prepared 3 h later. The distribution of 7-methylguanine was found to be random between these classes of DNA. We have also studied chromatin DNA from rats treated with unlabelled DMN plus [3H]thymidine in this way, in order to find if DMN affects DNA synthesis within any one kinetic class. Our results suggest that there is no difference in the extent of synthesis between these classes. © 1978 Information Retrieval Limited.

引用

页码：3357 / 3364

页数：8

共 20 条

[1] REDUCED DNA-REPAIR IN MOUSE SATELLITE DNA AFTER TREATMENT WITH METHYLMETHANESULFONATE, AND N-METHYL-N-NITROSOUREA [J].