EXPRESSION OF THE GANGLIOSIDE GD3 IN HUMAN MENINGIOMAS IS ASSOCIATED WITH MONOSOMY OF CHROMOSOME-22

被引：22

作者：

FREDMAN, P ^{[1
]}

DUMANSKI, J ^{[1
]}

DAVIDSSON, P ^{[1
]}

SVENNERHOLM, L ^{[1
]}

COLLINS, VP ^{[1
]}

机构：

[1] KAROLINSKA HOSP,LUDWIG INST CANC RES,S-10401 STOCKHOLM 60,SWEDEN

来源：

JOURNAL OF NEUROCHEMISTRY | 1990年 / 55卷 / 06期

关键词：

Chromosome; 22; Gangliosides; GD3; Meningiomas; Molecular genetics;

D O I：

10.1111/j.1471-4159.1990.tb05765.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract: The ganglioside composition of 59 meningiomas has been compared with a molecular genetic analysis of chromosome 22 in the same specimens. Major gangliosides were GM3 (II3NeuAc‐LacCer) and/orGD3 [II3(NeuAc)2‐LacCer]. In specimens with no or partial deletions of chromosome 22, the GM3 ganglioside predominated, and the mean value for GM3, 61% of total sialic acid, was around four times higher than that for GD3. A loss of chromosome 22, found in 56% of the specimens, was shown to be associated with an increase in the proportion of ganglioside GD3, with the ratio between mean values of GM3 and GD3 being ∼ 1:1. Logistic regression revealed that the probability of predicting monosomy of chromosome 22 by the GD3 proportion was 66%. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：1838 / 1840

页数：3

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