PHOSPHOLIPID PEROXIDATION INDUCED BY THE CATECHOL-FE-3+(CU-2+) COMPLEX - A POSSIBLE MECHANISM OF NIGROSTRIATAL CELL-DAMAGE

被引：49

作者：

SOTOMATSU, A

NAKANO, M

HIRAI, S

机构：

[1] GUNMA UNIV,COLL MED CARE & TECHNOL,MAEBASHI,GUNMA 371,JAPAN

[2] GUNMA UNIV HOSP,DIV NEUROL,MAEBASHI,GUNMA 371,JAPAN

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1990年 / 283卷 / 02期

关键词：

D O I：

10.1016/0003-9861(90)90651-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ferric or cupric ions significantly promoted a peroxidative cleavage of unsaturated phospholipids in liposomes in vitro after coordinating with dopa and dopamine. Either α-tocopherol or desferrioxamine completely abolished the dopa-Fe3+ complex-induced phospholipid peroxidation, while superoxide dismutase, catalase, or sodium benzoate did not. A ferroxidase, ceruloplasmin, significantly inhibited the lipid peroxidation induced by the dopa-Fe3+ complex, indicating the importance of the reduction of the iron moiety in the complex for the lipid peroxidation. A possible mechanism of dopa-Fe3+ complex-induced phospholipid peroxidation is that oxene complexes, such as Fe(V)O and Fe(IV)O, produced abstract hydrogen atoms in unsaturated phospholipids to initiate lipid peroxidation. © 1990.

引用

页码：334 / 341

页数：8

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