SIGMA-RECEPTOR BLOCKADE BY BMY-14802 AFFECTS ENKEPHALINERGIC AND TACHYKININ CELLS DIFFERENTIALLY IN THE STRIATUM OF THE RAT

被引：5

作者：

ANGULO, JA ^{[1
]}

CADET, JL ^{[1
]}

MCEWEN, BS ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT NEUROL,PRECLIN NEUROSCI LAB,NEW YORK,NY 10032

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 175卷 / 02期

关键词：

(In situ hybridization); BMY; 14802; Neuroleptics; Proenkephalin; Protachykinin;

D O I：

10.1016/0014-2999(90)90236-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We determined proenkephalin and protachykinin mRNA levels in the striatum of the rat by in situ hybridization histochemistry in controls and in animals treated for 14 days with the potential neuroleptic drug BMY 14802 (15 mg/kg i.p.). Proenkephalin mRNA levels were increased relative to control values by 107, 88 and 94% and protachykinin mRNA levels decreased by 17, 28 and 10% in the rostral, medial and caudal aspects of the caudate-putamen, respectively. The data suggest that σ receptor activity, directly or indirectly, affects proenkephalin and protachykinin mRNA expression in striatal neurons. © 1990.

引用

页码：225 / 228

页数：4

共 10 条

[1] [Anonymous], 1979, STEREOTAXIC ATLAS RA
[2] STRIATAL TACHYKININ BIOSYNTHESIS - REGULATION OF MESSENGER-RNA AND PEPTIDE LEVELS BY DOPAMINE AGONISTS AND ANTAGONISTS
BANNON, MJ
ELLIOTT, PJ
BUNNEY, EB
[J]. MOLECULAR BRAIN RESEARCH, 1987, 3 (01): : 31 - 37
[3] GUNDLACH AL, 1986, J NEUROSCI, V6, P1757
[4] 3 RAT PREPROTACHYKININ MESSENGER-RNAS ENCODE THE NEUROPEPTIDES SUBSTANCE-P AND NEUROKININ-A
KRAUSE, JE
CHIRGWIN, JM
CARTER, MS
XU, ZS
HERSHEY, AD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (03) : 881 - 885
[5] PEROUTKA SJ, 1980, AM J PSYCHIAT, V137, P1518
[6] ROSEN H, 1984, J BIOL CHEM, V259, P4309
[7] SIGMA-OPIATES AND CERTAIN ANTIPSYCHOTIC-DRUGS MUTUALLY INHIBIT (+)-[H-3]SKF-10,047 AND [H-3]HALOPERIDOL BINDING IN GUINEA-PIG BRAIN MEMBRANES
TAM, SW
COOK, L
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (17): : 5618 - 5621
[8] INCREASE OF PROENKEPHALIN MESSENGER-RNA AND ENKEPHALIN CONTENT OF RAT STRIATUM AFTER DAILY INJECTION OF HALOPERIDOL FOR 2 TO 3 WEEKS
TANG, F
COSTA, E
SCHWARTZ, JP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (12): : 3841 - 3844
[9] POTENTIAL ANTIPSYCHOTIC BMY-14802 SELECTIVELY BINDS TO SIGMA-SITES
TAYLOR, DP
DEKLEVA, J
[J]. DRUG DEVELOPMENT RESEARCH, 1987, 11 (01) : 65 - 70
[10] MESENCEPHALIC DOPAMINE NEURONS REGULATE THE EXPRESSION OF NEUROPEPTIDE MESSENGER-RNAS IN THE RAT FOREBRAIN
YOUNG, WS
BONNER, TI
BRANN, MR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (24) : 9827 - 9831

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