HIGH-YIELD PREPARATION OF PURE 2-RADIOIODO-KETANSERIN OF HIGH SPECIFIC ACTIVITY, A SEROTONIN S2 RECEPTOR TRACER FOR SPECT

被引：12

作者：

MERTENS, J

GYSEMANS, M

BOSSUYTPIRON, C

THOMAS, M

机构：

[1] VUB Cyclotron, Vrije Universiteit Brussel, Brussels, 1090

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1990年 / 28卷 / 06期

关键词：

D O I：

10.1002/jlcr.2580280614

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of pure and high specific activity 2‐radioiodo‐Ketanserin is described. The Cu(1) assisted nucleophilic non‐isotopic exchange applied on 0.5 mg 2‐Br‐Ketanserin allows to obtain a labelling yield ≧ 90%. After appropriate semi‐preparative HPLC separation the tracer is further purified by means of a mini RP column technique, thus avoiding the inconveniences of evaporation of eluent. An overall radiochemical yield exceeding 75% of 2‐123I‐Ketanserin with a purity ≧ 99% ready for i.v. injection is obtained. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：731 / 738

页数：8