LYOPHILIZATION OF PHARMACEUTICAL INJECTIONS - THEORETICAL PHYSICAL MODEL

被引：23

作者：

HO, NFH

ROSEMAN, TJ

机构：

[1] UPJOHN CO,PHARM RES,KALAMAZOO,MI 49001

[2] UNIV MICHIGAN,COLL PHARM,ANN ARBOR,MI 48109

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 09期

关键词：

Dosage forms; parenteral—lyophilization; physicochemical model; Lyophilization—physicochemical model; parenteral formulations; Models; physicochemical—lyophilization;

D O I：

10.1002/jps.2600680930

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A physical model for the lyophilization kinetics of parenteral formulations is presented. Mathematical relationships are derived, which involve the simultaneous change in the receding boundary of the ice‐vapor interface with time as well as water vapor diffusion across the dry porous matrix and boundary layer. Heat from an external heat source is transferred across the frozen solution to the receding ice surface. The model predicts that the water lost and the receding boundary distance are linearly related to the square root of time when lyophilization is matrix controlled. The mathematical descriptions are predictive of the physicochemical and transport events and can lead to the design of quantitative experiments to relate theory to formulation design. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1170 / 1174

页数：5

共 30 条

[1]

BIRD RB, 1960, TRANSPORT PHENOMENA, P744

[2] LYOPHILIZATION OF PHARMACEUTICALS .4. DETERMINATION OF EUTECTIC TEMPERATURES OF INORGANIC SALTS [J].